Heritabilty Factors in Cervical Cancer

Grant number: 509002 | Funding period: 2008 - 2011

Completed

Abstract

Cervical cancer (neck of womb) is caused by human papillomavirus (HPV). Most women clear this very common virus. However persistent HPV infection can cause abnormal changes to cervical cells as found on Pap smears. Genetic factors may determine why such women ultimately develop cancer. A way to evaluate environmental from genetic effects is to study twins. If the risk is greater in indentical twins as compared to nonidentical it is more like to be due to genetics.

Related publications (3)

Genetic and Environmental Factors in Invasive Cervical Cancer: Design and Methods of a Classical Twin Study

DA MacHalek, JD Wark, SN Tabrizi, JL Hopper, M Bui, GS Dite, AM Cornall, M Pitts, D Gertig, B Erbas, SM Garland

2017-02-01

Background: Persistent high-risk human papillomavirus (HPV) infection is a necessary prerequisite for development of cervical canc..

The roles of genetic and environmental factors on risk of cervical cancer: A review of classical twin studies

EE Moore, JD Wark, JL Hopper, B Erbas, SM Garland

2012-02-01

Cervical cancer is the third most common cancer in women worldwide. Persistent infection with an oncogenic human papillomavirus (H..

Human papillomavirus genotype detection from Archival Papanicolaou-stained cervical tests

SN Tabrizi, N Taylor, MJ McCullough, G Phillips, J Wark, D Gertig, RW Petersen, M Saville, SM Garland

2010-12-01

BACKGROUND: Archival Papanicolaou (Pap)-stained cervical cytology tests may be the only source of a clinical sample for the evalua..

University of Melbourne Researchers

Suzanne Wark

John Wark